Under the fast-paced lifestyle of modern society, metabolic diseases known as the “four highs” – hypertension, hyperglycemia, hyperlipidemia and hyperuricemia – have become “invisible killers” threatening the health of the nation. The latest “Report on the Nutrition and Chronic Disease Status of Chinese Residents” shows that the prevalence of hyperglycemia among adults in China has reached 11.9%, the prevalence of hyperlipidemia has reached 35.6%, and the number of patients with hyperuricemia has exceeded 200 million. What is even more alarming is that the “four highs” diseases are no longer exclusive to the middle-aged and elderly. The middle-aged and young people aged 30 to 45 are becoming the main force of the disease. Today’s science popularization class will deeply analyze the health connection between abnormal blood ketones and “three highs” (high blood sugar, high blood lipid, and high uric acid), and introduce how the SEJOY multi-functional electrochemical detector provides a scientific basis for metabolic health management by simultaneously detecting four key indicators.
I. Unveiling the Mystery of Metabolic Abnormalities: The Chain Reaction from Blood Ketones to “Three Highs”
The metabolic system of the human body is like a sophisticated “chemical factory”, with the metabolic processes of sugar, fat and protein interlinked. When any one of these links is disrupted, it may trigger a domino-like health crisis.
(1) Blood ketones: The “Barometer” of Fat Metabolism
Blood ketones are intermediate products of fat breakdown. Under normal circumstances, the concentration of ketone bodies in the blood is maintained at 0.03-0.5mmol/L. When the body is in a state of hunger, engages in intense exercise or suffers from diabetic ketoacidosis, blood ketone levels will abnormally increase. Studies have shown that long-term mild elevation of blood ketones (0.5-3mmol/L) may indicate enhanced fat catabolism and is closely related to metabolic syndromes such as non-alcoholic fatty liver disease and obesity.
(2) Hyperglycemia: The “Fuse” of Metabolic Disorders
The normal range of fasting blood glucose is 3.9 to 6.1mmol/ L. When fasting blood glucose is ≥7.0mmol/L or 2-hour postprandial blood glucose is ≥11.1mmol/L, diabetes can be diagnosed. Persistent hyperglycemia can lead to the deposition of advanced glycation end products (AGEs) on the vessel walls, damaging vascular endothelial function, and simultaneously inducing insulin resistance, further exacerbating abnormal fat and uric acid metabolism. A 2024 study in a sub-journal of The Lancet showed that for every 1mmol/L increase in blood sugar, the risk of hyperlipidemia increases by 12% and the risk of hyperuricemia increases by 8%.
(3) Hyperlipidemia: The “Silent Killer” of Vascular Health
Lipid testing mainly focuses on four indicators: total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Among them, LDL-C is known as “bad cholesterol”, and the normal reference value should be less than 3.4mmol/L. When lipid metabolism is abnormal, lipids are prone to deposit on the vessel walls to form atherosclerotic plaques, which is the primary risk factor for cardiovascular and cerebrovascular diseases.
(4) Hyperuricemia: “Hidden Damage” to Joints and Kidneys
Uric acid is the end product of purine metabolism. The normal uric acid level for men is 150-416μmol/L, and for women, it is 89-357μmol/L. When uric acid is produced in excessive amounts or excreted in reduced amounts, urate crystals will form and deposit in the joint cavities and kidneys, causing gouty arthritis and kidney stones. The latest research has found that hyperuricemia can also aggravate insulin resistance and vascular damage by activating inflammatory response pathways.
Ii. Synergistic Hazards of the “Four Highs” : The Fatal Trap of Metabolic Syndrome
Clinical data shows that people with two or more metabolic abnormality indicators have a 3.2 times higher risk of cardiovascular diseases and a 5.6 times higher risk of diabetes than healthy people. This “1+1 > 2″ synergistic harm is mainly reflected in three aspects:
The vicious cycle of insulin resistance: Insulin resistance caused by high blood sugar leads to an increase in fat breakdown, with free fatty acids entering the liver to promote the synthesis of triglycerides, while inhibiting the excretion of uric acid, forming a chain reaction of “high blood sugar → high blood lipid → high uric acid”.
Oxidative stress and inflammatory response: Under the “four highs” state, the body generates a large number of reactive oxygen free radicals, activating inflammatory pathways such as NF-κB, leading to vascular endothelial dysfunction and a decrease in glomerular filtration rate, and ultimately inducing serious complications such as coronary heart disease and renal failure.
Metabolic memory effect: Long-term poor control of blood sugar and blood lipids can lead to the formation of “metabolic memory”. Even if the indicators return to normal later, the damage to target organs may still continue to progress. This is also an important reason for emphasizing the regular monitoring of metabolic indicators.
Iii. SEJOY Multi-functional Electrochemical Detector: An Innovative Solution for Simultaneous detection of Four Indicators
In metabolic health management, the detection of a single indicator is like “the blind men touching the elephant”, making it difficult to comprehensively reflect the body’s metabolic status. The multi-functional electrochemical detector developed by SEJOY adopts biosensing technology. With just one drop of blood, it can complete the detection of four indicators: blood ketone, blood sugar, cholesterol (total cholesterol), and uric acid, bringing a revolutionary breakthrough to metabolic health monitoring.
(1) Core Function: Simultaneous detection of four indicators, covering the core needs of metabolic health
The Sejoy multi-functional electrochemical detector takes “one-stop detection” as its core design concept and integrates the following key functions:
1. Blood glucose test
Detection range: 0.5-33.3mmol/L (applicable to multiple scenarios such as fasting and postprandial), supports peripheral whole blood samples, only requires 0.6μL of blood collection, and provides values within 5 seconds, meeting the daily monitoring needs of diabetic patients.
Accuracy: Complies with the ISO 15197:2015 international standard, with an error range of ≤±15%, ensuring data reliability.
2. Blood ketone test
Clinical value: For the risk warning of diabetic ketoacidosis (DKA), the detection range is 0.1 to 8.0mmol/L, the blood collection volume is 0.8μL, and the results are available within 5 seconds, providing a safety monitoring basis for patients undergoing insulin treatment.
3. Blood uric acid test
Detection range: 180-1190μmol/ L. It adopts the uricase-peroxidase method, which has strong anti-interference ability (not affected by substances such as vitamin C and bilirubin), and assists in the management of gout and hyperuricemia.
4. Total cholesterol test
Detection range: 2.6 to 10.4mmol/L, covering the normal, marginal elevated and hypercholesterolemia ranges. Blood collection volume: 1.5μL, value available within 25 seconds, facilitating risk assessment of cardiovascular diseases.
Core advantage: Four indicators share one host. Detection switching can be achieved by changing the corresponding test strips, without the need for additional equipment, thus saving space and costs.
(2) Technical Highlights: Electrochemical sensing + intelligent algorithms, balancing accuracy and convenience
1. Electrochemical sensing technology
Glucose dehydrogenase (FAD-GDH) test strips (for blood glucose) and specific enzyme electrodes (for blood ketone, uric acid, and cholesterol) are adopted to avoid oxygen interference and enhance the stability of the test. The electrodes are coated with nano-scale coatings to enhance the efficiency of electron conduction and shorten the reaction time.
2. Intelligent function integration
Automatic calibration: Each box of test strips is equipped with a built-in calibration chip. Once inserted into the main unit, it automatically recognizes the batch number and completes the calibration, eliminating the need for manual input and reducing operational errors.
Data Management: Supports storage of 800 sets of detection data, classified and statistically analyzed by indicators, displays 7/14/30-day average values and trend charts, compatible with Bluetooth connection to mobile phone apps (supporting iOS/Android), and generates personalized health reports.
Environmental adaptability: Operating temperature range: 5 to 45℃, humidity range: 0% to 90%, suitable for various scenarios such as home and community medical care.
3. Safety design
Anti-misoperation reminder: Automatic error reports will occur when the blood is not sucked, the blood volume is insufficient, or the test strip has expired to avoid invalid tests.
Blood collection needle safety: It is equipped with disposable sterile blood collection needles, with a hidden tip design to reduce the risk of punctures and meet the safety standards for medical devices.
Iv. Building a “Protective net” for Metabolic Health: A Scientific Management Model Combining Detection and Intervention
The prevention and treatment of metabolic abnormalities require a closed-loop management of “detection – assessment – intervention – re-assessment”. The SEJOY multi-functional electrochemical detector is not only a detection tool but also an “intelligent assistant” for health management.
(1) Precise detection guides scientific intervention
Take diabetic patients as an example. When blood glucose is detected to be greater than 13.9mmol/L and blood ketone is greater than 0.6mmol/L, it indicates a risk of ketosis. Insulin dosage should be adjusted immediately and water should be replenished. If blood ketone levels remain persistently above 3mmol/L, medical attention should be sought promptly to rule out diabetic ketoacidosis.
(2) “Quantitative Navigation” for Lifestyle Intervention
In dietary management, an individual’s metabolic response to different foods can be identified by monitoring the changes in blood sugar and blood ketone two hours after a meal. For instance, if someone’s blood sugar levels rise sharply after consuming refined carbohydrates, but the fluctuations are significantly reduced after choosing whole grains and high-quality protein, these personalized data can provide a basis for adjusting dietary plans.
In terms of exercise intervention, detecting changes in blood ketones after aerobic exercise can assess the efficiency of fat burning. Generally, it is recommended to control the exercise intensity within the range of blood ketone < 1.5mmol/L to avoid excessive exercise leading to ketosis.
(3) The “Home Assistant” for Chronic Disease Management
For patients with hyperlipidemia and hyperuricemia who need to take medication for a long time, regular use of the SEJOY detector to monitor changes in indicators can promptly identify the efficacy of drugs and adverse reactions. If cholesterol levels are too low (< 2.6mmol/L) during statin treatment, the dosage should be adjusted under the guidance of a doctor.
Ⅴ. Make scientific testing a “standard feature” of a healthy life
The concept of health management is undergoing a profound transformation from “treating existing diseases” to “preventing diseases before they occur”. The SEJOY multi-functional electrochemical detector, with its rapid, accurate and convenient features, has brought metabolic index detection from hospital laboratories to daily household use. It is recommended that every person over 35 years old, obese individuals, and those with a family history of diabetes include the detection of four metabolic indicators in their annual health check-up items. Through regular monitoring, early detection and intervention of metabolic abnormalities can be achieved.
Health is the most precious wealth in life, and scientific health management needs to be based on precise detection data. Let’s join hands with the SEJOY multi-functional electrochemical detector, take the initiative to grasp the “initiative” of metabolic health, and jointly safeguard the metabolic balance of life!
Post time: Dec-24-2025