The kidneys, the “silent guardians” located behind the peritoneum, silently filter about 200 liters of blood every day, equivalent to the volume of 100 large barrels of water. However, in China, the awareness rate of chronic kidney disease (CKD) is only 12.5%, and over 120 million patients are in the hidden progression stage of the disease. When obvious symptoms occur, kidney function is often lost by more than 70%. This article will systematically analyze the hazards of chronic kidney disease and early screening strategies, and focus on introducing the significant role of Sejoy urine analysis test strips in kidney health management.
I. Chronic Kidney Disease: The “Hidden Killer” Lurking Around Us
Chronic kidney disease refers to abnormalities in the structure or function of the kidneys caused by various reasons that persist for more than three months, and its progression is irreversible. The latest epidemiological survey shows that the prevalence rate of chronic kidney disease among adults in China is as high as 10.8%, which means that one in every nine adults has impaired kidney function. What is even more worrying is that the risk of chronic kidney disease patients developing end-stage renal disease (uremia) is 10 to 20 times that of healthy people, and the mortality rate of cardiovascular diseases is 3 to 5 times that of the general population.
The compensatory function of the kidneys is extremely strong, and early lesions often have no typical symptoms. Clinical data show that when blood creatinine levels rise significantly, the glomerular filtration rate has dropped by more than 50%. Hypertension, diabetes, obesity and hyperuricemia are the four major high-risk factors for chronic kidney disease. Among them, diabetic nephropathy has become the leading cause of end-stage renal disease, accounting for more than 40% of the total number of dialysis patients. Long-term use of non-steroidal anti-inflammatory drugs, traditional Chinese medicines containing aristolochic acid and other medications can also increase the risk of kidney damage.
Ii. Urine Testing: The “Barometer” of Kidney Health
Urine is the most direct “window” of kidney function, containing information on over 1,000 kinds of metabolites. In the early stage of kidney injury, abnormal components such as trace amounts of protein and red blood cells will appear in the urine. These changes occur 3 to 5 years earlier than abnormal blood indicators. The International Society of Nephrology (ISN) strongly recommends urine testing as the core method for screening chronic kidney disease, especially for high-risk groups, urine analysis should be conducted every six months.
Traditional urine tests have many limitations: routine urine tests can only qualitatively detect eight indicators and are not sensitive to early damage markers such as microalbumin. Although 24-hour urine protein quantification is accurate, the operation is cumbersome and patients have poor compliance. The emergence of Sejoy urine analysis test strips has completely transformed the landscape of early screening for kidney diseases. Its 14 detection indicators cover multiple dimensions of kidney damage, achieving a leap from qualitative to semi-quantitative.
Iii. Sejoy Urine Analysis Test Strips: A Powerful Tool for Multi-dimensional Kidney health monitoring
As a professional-grade in vitro diagnostic product, Sejoy urine analysis test strips adopt multi-layer film chemical coloration technology and can simultaneously detect 14 key indicators in urine, providing comprehensive information for the early diagnosis of kidney diseases. This test strip is composed of an absorbent layer, a reactive layer and a supporting layer. Different detection items show different color changes through the reaction of specific chemical reagents with urine components. When used in conjunction with a urine analyzer, it can achieve semi-quantitative detection, with a detection range covering a wide range from trace amounts to pathological concentrations.
(1) Analysis of Core Testing Indicators
Markers of kidney injury
Microalbumin is a specific indicator of early damage to the glomerular filtration membrane, with a normal value of less than 30mg/L. When the microalbumin in urine is within the range of 30-300mg/L, it indicates early diabetic nephropathy or hypertensive renal damage. At this point, intervention treatment can reverse the condition. Sejoy test strips use immunochromatography, with a detection sensitivity of 10mg/L, which can detect kidney damage 2-3 years earlier than traditional urine routine tests.
The ratio of Creatinine to urine microalbumin (ACR) is the gold standard for evaluating glomerular injury. The normal ACR is less than 30mg/g, 30-300mg/g is the microalbuminuria stage, and more than 300mg/g indicates massive proteinuria. Sejoy test strips simultaneously detect creatinine and microalbumin, and automatically calculate the ACR value, avoiding the drawback of albumin detection alone being affected by urine concentration and dilution.
Monitoring of metabolic disorders
Positive Glucose indicates that the blood glucose level exceeds the renal glucose threshold (8.88mmol/L), and it is an important indicator for the diagnosis of diabetes and blood glucose control. Ketone positivity is commonly seen in diabetic ketoacidosis. At this time, emergency intervention is needed to prevent coma. The pH value reflects the acid-base balance of urine. Persistent acidic urine (pH < 5.5) is prone to form uric acid stones, while alkaline urine (pH > 7.0) is prone to form calcium phosphate stones.
Infection and bleeding indicators
The combined detection of white blood cells (Leukocytes) and Nitrite (Nitrite) has significant diagnostic value for urinary tract infections. When both are positive, the specificity for diagnosing urinary tract infections reaches 95%. Positive Blood indicators suggest glomerular hematuria or urinary tract injury, and it is necessary to combine the analysis of red blood cell morphology for differential diagnosis.
(2) Advantages in clinical application
Sejoy test strips have unparalleled technical advantages: 14 indicators can be simultaneously detected in just 2 minutes, and the detection sensitivity reaches the ng level. The anti-vitamin C interference technology is adopted to avoid the false negative impact of high-concentration vitamin C on indicators such as glucose and occult blood. The test strips are packaged with inert materials and can be stably stored for 24 months in an environment ranging from 2 to 30℃.
In the screening of diabetic nephropathy, the microalbumin detection sensitivity of Sejoy test strips reached 92.3%, and the specificity was 88.7%, which was significantly better than that of traditional urine routine tests (sensitivity 65.4%). For patients with hypertension, regular testing of urine microalbumin can predict the risk of cardiorenal events. Studies have shown that for every 10mg/g increase in ACR, the risk of cardiovascular death rises by 14%.
Iv. Professional Application Norms and Clinical Value
Sejoy urine analysis test strips, as IVD products, are only for use in professional medical institutions. The correct operation process includes: collecting clean midstream urine and completing the test within 2 hours; Immerse the test strip completely in the urine for 1-2 seconds, remove the excess urine and wait for 120 seconds (the reaction time varies for different indicators). Read the results using the accompanying urine analyzer to avoid errors in visual interpretation. In clinical practice, a comprehensive judgment should be made based on the patient’s medical history, physical signs and other examination results. A single abnormality needs to be rechecked and confirmed within two weeks.
In the management of chronic kidney disease, Sejoy test strips can achieve full-process monitoring: identifying high-risk groups in the early screening stage; Assist in determining the lesion site (glomerulus/renal tubules) during the diagnostic stage; During the treatment stage, the efficacy of drugs is evaluated, such as the effect of ACEI drugs in reducing urinary protein. During the follow-up stage, disease progression is warned. When microalbumin levels continue to rise by more than 30%, it indicates a deterioration of the condition. Data from a top-tier hospital shows that after using Sejoy test strips for annual screening of diabetic patients, the early diagnosis rate of diabetic nephropathy increased by 58%, and the demand for dialysis decreased by 32%.
V. Prevention and Management Strategies for Chronic Kidney Disease
The prevention and treatment of chronic kidney disease follow the “Three Early principles” : early screening, early intervention, and early treatment. For the general population, it is recommended to have a routine urine test once a year. High-risk groups (such as those with diabetes, hypertension, and obesity) should have their urine microalbumin/creatinine ratio tested every six months. Lifestyle intervention includes: drinking 1500-2000ml of water daily and maintaining a urine output of more than 1500ml. Low-salt diet (< 5g per day), and avoid high-protein diet (no more than 1.0g/kg of body weight); Keep the body mass index (BMI) between 18.5 and 23.9. Quit smoking and limit alcohol intake. Avoid staying up late and overwork.
In terms of drug treatment, angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor antagonists (ARB) can not only lower blood pressure but also reduce urinary protein excretion and delay the deterioration of renal function. Studies have confirmed that keeping urine protein below 0.3g per day can reduce the risk of chronic kidney disease progression by 50%. For diabetic patients, strictly controlling blood sugar (glycated hemoglobin < 7%) can reduce the incidence of microalbuminuria by 33%.
Conclusion
Kidney health is related to the quality of life, and early screening is the key to blocking the progression of chronic kidney disease. Sejoy URINALYSIS REAGENT STRIPS, with their 14 comprehensive detection indicators, professional-level detection accuracy and convenient operation process, have become an important tool for the early diagnosis of kidney diseases. Under the guidance of a professional medical team, by incorporating regular urine testing into the health management system and combining it with scientific intervention measures, we can fully achieve early detection and treatment of chronic kidney disease, and safeguard this pair of precious “life filters”. Remember: The kidneys cannot speak, but they are always sending us health signals through urine. Only by understanding these signals can we truly protect our life-giving kidneys.
Post time: Dec-27-2025